Research on Liebeskind-Srogl coupling/intramolecular Diels-Alder reaction cascade

Tomohiro Fujii, Yuta Oki, Masahisa Nakada*

*この研究の対応する著者

研究成果: Article査読

3 被引用数 (Scopus)

抄録

The Liebeskind-Srogl coupling/intramolecular Diels-Alder (IMDA) reaction cascade that stereoselectively affords a tricarbocyclic compound with a trans–trans-cis fused ring system including an all-carbon quaternary stereogenic center at the ring junction is described. The cascade reactions proceed quickly and stereoselectively afford the products within 2 h at room temperature in the presence of a suitable thioester. The developed protocol as well as the prepared chiral compounds are useful for the enantioselective total synthesis of terpenoids with the trans–trans-cis fused ring system.

本文言語English
ページ(範囲)882-886
ページ数5
ジャーナルTetrahedron Letters
59
10
DOI
出版ステータスPublished - 2018 3月 7

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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