TY - JOUR
T1 - Sattahipmycin, a Hexacyclic Xanthone Produced by a Marine-Derived Streptomyces
AU - Leetanasaksakul, Kantinan
AU - Koomsiri, Wilaiwan
AU - Suga, Takuya
AU - Matsuo, Hirotaka
AU - Hokari, Rei
AU - Wattana-Amorn, Pakorn
AU - Takahashi, Yō Ko
AU - Shiomi, Kazuro
AU - Nakashima, Takuji
AU - Inahashi, Yuki
AU - Thamchaipenet, Arinthip
N1 - Funding Information:
We are grateful to Distinguished Emeritus Professor Satoshi O̅mura (Kitasato University) for his helpful support and valuable suggestions. We thank Chakrit Bunyoo and Sasithorn Chotewutmontri, Chulabhorn Royal Academy, Thailand, for bacterial whole genome sequencing by PacBio Sequel systems. W.K. was granted the Postdoctoral Fellowship from Kasetsart University. K.L. and this work was financially supported by JSPS-NRCT under the Japan-Thailand Research Cooperative Program; the Institute for Fermentation, Osaka (IFO), Japan; and Omics Center for Agriculture, Bioresources, Food and Health, Kasetsart University (OmiKU), Thailand.
Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.
PY - 2022/5/27
Y1 - 2022/5/27
N2 - Sattahipmycin was isolated from the mycelium of marine-derived Streptomyces sp. GKU 257-1 by following the antibiofilm activity against E. coli NBRC 3972 throughout the purification steps. The structure of sattahipmycin was determined to be a new polycyclic xanthone related to xantholipin but lacking a dioxymethylene and a chlorinated carbon. This compound showed activity toward Gram-positive bacteria and Plasmodium falciparum, antibiofilm formation of Escherichia coli, and cytotoxicity to human cancer cell lines. Using genome sequence data, a biosynthetic pathway leading to sattahipmycin has been proposed involving an uncharacterized type II polyketide synthase biosynthetic gene cluster.
AB - Sattahipmycin was isolated from the mycelium of marine-derived Streptomyces sp. GKU 257-1 by following the antibiofilm activity against E. coli NBRC 3972 throughout the purification steps. The structure of sattahipmycin was determined to be a new polycyclic xanthone related to xantholipin but lacking a dioxymethylene and a chlorinated carbon. This compound showed activity toward Gram-positive bacteria and Plasmodium falciparum, antibiofilm formation of Escherichia coli, and cytotoxicity to human cancer cell lines. Using genome sequence data, a biosynthetic pathway leading to sattahipmycin has been proposed involving an uncharacterized type II polyketide synthase biosynthetic gene cluster.
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U2 - 10.1021/acs.jnatprod.1c00870
DO - 10.1021/acs.jnatprod.1c00870
M3 - Review article
C2 - 35512262
AN - SCOPUS:85130032904
SN - 0163-3864
VL - 85
SP - 1211
EP - 1217
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 5
ER -
