Schulzeines A-C, New α-Glucosidase Inhibitors from the Marine Sponge Penares schulzei

Kentaro Takada; Taisuke Uehara; Yoichi Nakao; Shigeki Matsunaga; Rob W.M. Van Soest; Nobuhiro Fusetani

doi:10.1021/ja037368r

Schulzeines A-C, New α-Glucosidase Inhibitors from the Marine Sponge Penares schulzei

Kentaro Takada, Taisuke Uehara, Yoichi Nakao, Shigeki Matsunaga, Rob W.M. Van Soest, Nobuhiro Fusetani^*

^*この研究の対応する著者

研究成果: Article › 査読

105 被引用数 (Scopus)

抄録

Three new α-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marine sponge Penares schulzei. Their structures were elucidated by spectral analysis and chemical degradations to be the isoquinoline alkaloids, encompassing two amino acids, and C₂₈ fatty acid, the last of which was sulfated. Absolute stereochemistry of schulzeines was determined by application of the modified Mosher analysis to fragments obtained by chemical degradation. Schulzeines A-C inhibit α-glucosidase with IC₅₀ values of 48-170 nM.

本文言語	English
ページ（範囲）	187-193
ページ数	7
ジャーナル	Journal of the American Chemical Society
巻	126
号	1
DOI	https://doi.org/10.1021/ja037368r
出版ステータス	Published - 2004 1月 14
外部発表	はい

ASJC Scopus subject areas

触媒
化学一般
生化学
コロイド化学および表面化学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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abstract = "Three new α-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marine sponge Penares schulzei. Their structures were elucidated by spectral analysis and chemical degradations to be the isoquinoline alkaloids, encompassing two amino acids, and C28 fatty acid, the last of which was sulfated. Absolute stereochemistry of schulzeines was determined by application of the modified Mosher analysis to fragments obtained by chemical degradation. Schulzeines A-C inhibit α-glucosidase with IC50 values of 48-170 nM.",

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AU - Takada, Kentaro

AU - Uehara, Taisuke

AU - Nakao, Yoichi

AU - Matsunaga, Shigeki

AU - Van Soest, Rob W.M.

AU - Fusetani, Nobuhiro

PY - 2004/1/14

Y1 - 2004/1/14

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AB - Three new α-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marine sponge Penares schulzei. Their structures were elucidated by spectral analysis and chemical degradations to be the isoquinoline alkaloids, encompassing two amino acids, and C28 fatty acid, the last of which was sulfated. Absolute stereochemistry of schulzeines was determined by application of the modified Mosher analysis to fragments obtained by chemical degradation. Schulzeines A-C inhibit α-glucosidase with IC50 values of 48-170 nM.

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Schulzeines A-C, New α-Glucosidase Inhibitors from the Marine Sponge Penares schulzei

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ASJC Scopus subject areas

UN SDG

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