@article{e5a3fe3691ae4f66945b6e37b9ced8b7,
title = "Shishicrellastatins, inhibitors of cathepsin B, from the marine sponge Crella (Yvesia) spinulata",
abstract = "Two dimeric steroid derivatives, shishicrellastatin A (1) and B (2), have been isolated as cathepsin B inhibitors from the marine sponge Crella (Yvesia) spinulata. Their structures were determined by interpretation of spectroscopic data. Shishicrellastatins inhibit cathepsin B with an IC 50 value of 8 μg/mL each.",
keywords = "Cathepsin B, Crellastatin, Dimeric, Sponge, Steroid, Structure elucidation",
author = "Shuhei Murayama and Yasufumi Imae and Kentaro Takada and Jo Kikuchi and Yoichi Nakao and {Van Soest}, {Rob W.M.} and Shigeru Okada and Shigeki Matsunaga",
note = "Funding Information: We thank the officers and crew of T/S Toyoshio-maru of Hiroshima University for their assistance in collecting the sponge. We thank Kanji Hori for the arrangement of the cruise. We also thank Dr. Kazuo Furihata of University of Tokyo for assistance in measuring NMR spectra. This work was partly supported by Grant-in-Aid for Scientific Research on Priority Areas 16073207 from MEXT. ",
year = "2011",
month = nov,
day = "15",
doi = "10.1016/j.bmc.2011.06.052",
language = "English",
volume = "19",
pages = "6594--6598",
journal = "Bioorganic and Medicinal Chemistry",
issn = "0968-0896",
publisher = "Elsevier Ltd",
number = "22",
}
