Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid

Masahiro Ogata; K. Oka; Masako Seki; Midori Hoshi; Hirokatsu Takatsu; Tadahiko Mashino; Shiro Urano; Toyoshige Endo

doi:10.1248/bpb.30.1565

Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid

Masahiro Ogata^*, K. Oka, Masako Seki, Midori Hoshi, Hirokatsu Takatsu, Tadahiko Mashino, Shiro Urano, Toyoshige Endo

^*この研究の対応する著者

研究成果: Article › 査読

3 被引用数 (Scopus)

抄録

Dipropofol has a strong antibacterial activity against Gram-positive bacteria. However, it lacked the solubility in water and this property was supposed to limit its efficacy. We tried to improve the solubility and found a new solubilization method of dipropofol in water by the addition of a monosaccharide or ascorbic acid.

本文言語	English
ページ（範囲）	1565-1568
ページ数	4
ジャーナル	Biological and Pharmaceutical Bulletin
巻	30
号	8
DOI	https://doi.org/10.1248/bpb.30.1565
出版ステータス	Published - 2007 8月
外部発表	はい

ASJC Scopus subject areas

分子医療
薬理学、毒性学および薬学（全般）

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10.1248/bpb.30.1565

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AU - Ogata, Masahiro

AU - Oka, K.

AU - Seki, Masako

AU - Hoshi, Midori

AU - Takatsu, Hirokatsu

AU - Mashino, Tadahiko

AU - Urano, Shiro

AU - Endo, Toyoshige

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KW - Dipropofol

KW - Monosaccharide

KW - Solubilization

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Solubilization of dipropofol, an antibacterial agent, using saccharide and ascorbic acid

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