Specific RNA protease inhibitors from in vitro selection.

S. Yamamoto; S. Saito; T. Tanaka; Yo Kikuchi

Specific RNA protease inhibitors from in vitro selection.

S. Yamamoto^*, S. Saito, T. Tanaka, Yo Kikuchi

^*この研究の対応する著者

研究成果: Article › 査読

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RNA aptamers that bind to and inhibit the proteolytic activity of subtilisin BPN' are selected in vitro from pools of random RNA. The RNAs in vitro transcribed from the isolated clones show highly specific inhibition toward the microbial serine proteases. From the sequences of the isolated clones, a C/A-rich sequence was obtained. The kinetic features of the common C/A-rich sequence will be discussed.

本文言語	English
ページ（範囲）	215-216
ページ数	2
ジャーナル	Nucleic acids symposium series
号	42
出版ステータス	Published - 1999
外部発表	はい

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title = "Specific RNA protease inhibitors from in vitro selection.",

abstract = "RNA aptamers that bind to and inhibit the proteolytic activity of subtilisin BPN' are selected in vitro from pools of random RNA. The RNAs in vitro transcribed from the isolated clones show highly specific inhibition toward the microbial serine proteases. From the sequences of the isolated clones, a C/A-rich sequence was obtained. The kinetic features of the common C/A-rich sequence will be discussed.",

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AU - Yamamoto, S.

AU - Saito, S.

AU - Tanaka, T.

AU - Kikuchi, Yo

PY - 1999

Y1 - 1999

N2 - RNA aptamers that bind to and inhibit the proteolytic activity of subtilisin BPN' are selected in vitro from pools of random RNA. The RNAs in vitro transcribed from the isolated clones show highly specific inhibition toward the microbial serine proteases. From the sequences of the isolated clones, a C/A-rich sequence was obtained. The kinetic features of the common C/A-rich sequence will be discussed.

AB - RNA aptamers that bind to and inhibit the proteolytic activity of subtilisin BPN' are selected in vitro from pools of random RNA. The RNAs in vitro transcribed from the isolated clones show highly specific inhibition toward the microbial serine proteases. From the sequences of the isolated clones, a C/A-rich sequence was obtained. The kinetic features of the common C/A-rich sequence will be discussed.

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C2 - 10780456

AN - SCOPUS:0033289171

SN - 0261-3166

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JO - Nucleic acids symposium series

JF - Nucleic acids symposium series

IS - 42

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Specific RNA protease inhibitors from in vitro selection.

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