Spontaneous oscillatory contraction of sarcomeres in skeletal myofibrils

Nobuyuki Okamura, Shin'ichi Ishiwata*


    研究成果: Article査読

    56 被引用数 (Scopus)


    We found that the lengths of all sarcomeres spontaneously oscillated in an isolated skeletal myofibril, when both ends were fixed, submillimolar to millimolar concentrations of ATP, ADP and inorganic phosphate (Pi) were present, and Ca2+ was removed. Narrowing and widening of an H-zone and an I-band were observed corresponding to the shortening and lengthening of a sarcomere, suggesting that thick and thin filaments slide past each other. The oscillation of each sarcomere was asymmetrical, consisting of a rapid lengthening phase and a slow shortening phase. The period of oscillation was about 3 s; the peak-to-peak amplitude of oscillation reached as much as 30% of the average sarcomere length. The propagation of the sarcomere oscillation along the long axis of the myofibril was observed occasionally in single myofibrils and frequently in bundles of myofibrils. The 'state'-diagram showing the concentration range of ADP and Pi in which contraction, oscillation or relaxation of myofibrils occurs in the presence of ATP and the absence of Ca2+ suggested that the oscillation is a third state of skeletal muscle located in between the contracting and relaxing states.

    ジャーナルJournal of Muscle Research and Cell Motility
    出版ステータスPublished - 1988 4月

    ASJC Scopus subject areas

    • 生理学
    • 内分泌学
    • 臨床生化学
    • 細胞生物学


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