Stable Generation of Single- Micron Droplets and Highly Efficient Encapsulation of Cells by Multi-Branch Channels

Seito Shijo; Shuichi Shoji; Daiki Tanaka; Tetsushi Sekiguchi; Masahiro Furuya

doi:10.1109/MEMS51670.2022.9699584

Stable Generation of Single- Micron Droplets and Highly Efficient Encapsulation of Cells by Multi-Branch Channels

Seito Shijo, Shuichi Shoji, Daiki Tanaka, Tetsushi Sekiguchi, Masahiro Furuya

研究成果: Conference contribution

抄録

We have developed an efficient, stable device for generating single-micrometer-scale (1-2 m) droplets based on the fragmentation of droplet tails by tailing. The device, created by a ple soft lithography process, induced continuous droplet fragmentation by branched channels under low-flow conditions (1-10 L/min). The flow rate and surfactant concentration were also important factors for droplet fragmentation. Examining 10 combinations of flow rate and surfactant concentration revealed the optimal conditions, which produced droplets less than 2 m in size at a generation rate of 61.1%. With this method, we efficiently encapsulated cell-mimicking microbeads into passively generated single-micrometer-scale microdroplets.

本文言語	English
ホスト出版物のタイトル	35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022
出版社	Institute of Electrical and Electronics Engineers Inc.
ページ	900-903
ページ数	4
ISBN（電子版）	9781665409117
DOI	https://doi.org/10.1109/MEMS51670.2022.9699584
出版ステータス	Published - 2022
イベント	35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022 - Tokyo, Japan 継続期間: 2022 1月 9 → 2022 1月 13

出版物シリーズ

名前	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
巻	2022-January
ISSN（印刷版）	1084-6999

Conference

Conference	35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022
国/地域	Japan
City	Tokyo
Period	22/1/9 → 22/1/13

ASJC Scopus subject areas

電子材料、光学材料、および磁性材料
凝縮系物理学
機械工学
電子工学および電気工学

文献へのアクセス

10.1109/MEMS51670.2022.9699584

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引用スタイル

Shijo, S., Shoji, S., Tanaka, D., Sekiguchi, T., & Furuya, M. (2022). Stable Generation of Single- Micron Droplets and Highly Efficient Encapsulation of Cells by Multi-Branch Channels. In 35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022 (pp. 900-903). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2022-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMS51670.2022.9699584

Stable Generation of Single- Micron Droplets and Highly Efficient Encapsulation of Cells by Multi-Branch Channels. / Shijo, Seito; Shoji, Shuichi; Tanaka, Daiki その他.
35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022. Institute of Electrical and Electronics Engineers Inc., 2022. p. 900-903 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2022-January).

研究成果: Conference contribution

Shijo, S, Shoji, S, Tanaka, D, Sekiguchi, T & Furuya, M 2022, Stable Generation of Single- Micron Droplets and Highly Efficient Encapsulation of Cells by Multi-Branch Channels. in 35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2022-January, Institute of Electrical and Electronics Engineers Inc., pp. 900-903, 35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022, Tokyo, Japan, 22/1/9. https://doi.org/10.1109/MEMS51670.2022.9699584

Shijo S, Shoji S, Tanaka D, Sekiguchi T, Furuya M. Stable Generation of Single- Micron Droplets and Highly Efficient Encapsulation of Cells by Multi-Branch Channels. In 35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022. Institute of Electrical and Electronics Engineers Inc. 2022. p. 900-903. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). doi: 10.1109/MEMS51670.2022.9699584

Shijo, Seito ; Shoji, Shuichi ; Tanaka, Daiki その他. / Stable Generation of Single- Micron Droplets and Highly Efficient Encapsulation of Cells by Multi-Branch Channels. 35th IEEE International Conference on Micro Electro Mechanical Systems Conference, MEMS 2022. Institute of Electrical and Electronics Engineers Inc., 2022. pp. 900-903 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

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abstract = "We have developed an efficient, stable device for generating single-micrometer-scale (1-2 m) droplets based on the fragmentation of droplet tails by tailing. The device, created by a ple soft lithography process, induced continuous droplet fragmentation by branched channels under low-flow conditions (1-10 L/min). The flow rate and surfactant concentration were also important factors for droplet fragmentation. Examining 10 combinations of flow rate and surfactant concentration revealed the optimal conditions, which produced droplets less than 2 m in size at a generation rate of 61.1%. With this method, we efficiently encapsulated cell-mimicking microbeads into passively generated single-micrometer-scale microdroplets.",

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AB - We have developed an efficient, stable device for generating single-micrometer-scale (1-2 m) droplets based on the fragmentation of droplet tails by tailing. The device, created by a ple soft lithography process, induced continuous droplet fragmentation by branched channels under low-flow conditions (1-10 L/min). The flow rate and surfactant concentration were also important factors for droplet fragmentation. Examining 10 combinations of flow rate and surfactant concentration revealed the optimal conditions, which produced droplets less than 2 m in size at a generation rate of 61.1%. With this method, we efficiently encapsulated cell-mimicking microbeads into passively generated single-micrometer-scale microdroplets.

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Stable Generation of Single- Micron Droplets and Highly Efficient Encapsulation of Cells by Multi-Branch Channels

抄録

出版物シリーズ

Conference

ASJC Scopus subject areas

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