Stimulation by proopiomelanocortin-derived peptides of LH release by bullfrog dispersed anterior pituitary cells

Tomomi Aida, Atsuko Oguchi, Shawichi Iwamuro, Kazutoshi Yamamoto, Sakae Kikuyama*

*この研究の対応する著者

    研究成果: Article査読

    5 被引用数 (Scopus)

    抄録

    Labeling and immunoprecipitation experiments confirmed that three proopiomelanocortin (POMC)-derived peptides, the N-terminal peptide of POMC (NPP), joining peptide (JP) and adrenocorticotropic hormone (ACTH), were released by the bullfrog (Rana catesbeiana) anterior pituitary. The effects of these three peptides on luteinizing hormone (LH) release by bullfrog dispersed anterior pituitary cells were studied. NPP and ACTH, but not JP, enhanced LH release concentration-dependently. Approximately 6 hr elapsed before the gonadotrophs responded to NPP and ACTH by releasing LH, whereas their response to human GnRH (hGnRH) was faster, suggesting that the modes of action of these two peptides and hGnRH differ. These results raise the possibility that NPP and ACTH act as paracrine factors in the bullfrog pituitary to enhance LH release either directly or indirectly.

    本文言語English
    ページ(範囲)827-831
    ページ数5
    ジャーナルZoological Science
    14
    5
    出版ステータスPublished - 1997 10月

    ASJC Scopus subject areas

    • 動物科学および動物学

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