TY - JOUR
T1 - Structure elucidation and enantioselective total synthesis of the HMG-CoA reductase inhibitors FR901512 and FR901516
AU - Inoue, Masahiro
AU - Nakada, Masahisa
PY - 2009
Y1 - 2009
N2 - The enantioselective total synthesis of the potent HMGCoA reductase inhibitors FR901512 (1) and FR901516 (2) is reviewed. FR901512 was prepared in 15 steps from commercially available compound via 2 in 16.3% overall yield (89% average yield). This study validated the applicability and reliability of the catalytic asymmetric Nozaki-Hiyama reactions that were developed by us. These reactions enabled the concise, efficient, and protecting-group-free enantioselective total syntheses of these new statins.
AB - The enantioselective total synthesis of the potent HMGCoA reductase inhibitors FR901512 (1) and FR901516 (2) is reviewed. FR901512 was prepared in 15 steps from commercially available compound via 2 in 16.3% overall yield (89% average yield). This study validated the applicability and reliability of the catalytic asymmetric Nozaki-Hiyama reactions that were developed by us. These reactions enabled the concise, efficient, and protecting-group-free enantioselective total syntheses of these new statins.
KW - Asymmetric catalysis
KW - Enantioselective synthesis
KW - Nozaki-Hiyama reaction
KW - Structure elucidation
KW - Total synthesis
UR - http://www.scopus.com/inward/record.url?scp=72049101650&partnerID=8YFLogxK
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U2 - 10.1055/S-0029-1216980
DO - 10.1055/S-0029-1216980
M3 - Review article
AN - SCOPUS:72049101650
SN - 0039-7881
SP - 3694
EP - 3707
JO - Synthesis
JF - Synthesis
IS - 21
ER -