抄録
Surface modification is an important part of the fabrication of nanoparticles that have specific properties and functions. Here we describe the development of a functional polypeptide and a simple available technology for surface modification of nanoparticles. A NS polypeptide, which is 100 amino acids composed of repeated units of four asparagine and one serine residue (NS), as a molecule for nanoparticle surface modification was designed. Modification of the surface of a magnetic nanoparticle with the NS polypeptide results in reduction of particle-particle and particle-cell interactions. When NS polypeptide is used in single fusion protein as a linker to display protein G on nanoparticles, the nanoparticle acquires the capacity to specifically bind target cells and to avoid nonspecific adsorption of non-target cells. This technology, incorporating a functional polypeptide, may represent a completely new strategy for surface modification of nanoparticles for use in a variety of cell-associated applications.
本文言語 | English |
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ページ(範囲) | 4952-4957 |
ページ数 | 6 |
ジャーナル | Biomaterials |
巻 | 31 |
号 | 18 |
DOI | |
出版ステータス | Published - 2010 6月 |
外部発表 | はい |
ASJC Scopus subject areas
- 生体材料
- バイオエンジニアリング
- セラミックおよび複合材料
- 材料力学
- 生物理学