Syn-selective kobayashi aldol reaction using the E,E-vinylketene silyl N,O -acetal

Yuki Mukaeda; Takuya Kato; Seijiro Hosokawa

doi:10.1021/ol3024677

Syn-selective kobayashi aldol reaction using the E,E-vinylketene silyl N,O -acetal

Yuki Mukaeda, Takuya Kato, Seijiro Hosokawa^*

^*この研究の対応する著者

先進理工学部

研究成果: Article › 査読

37 被引用数 (Scopus)

抄録

The Kobayashi aldol reaction is one of the most powerful methods to synthesize the polyketide skeleton and has been applied to the total synthesis of natural products. This methodology has been used to construct anti-aldol products, and only a few precedents on the syn-selective Kobayashi aldol reaction are known. A syn-selective Kobayashi aldol reaction by using the E,E-vinylketene silyl N,O-acetal and an excess amount of Lewis acid is presented.

本文言語	English
ページ（範囲）	5298-5301
ページ数	4
ジャーナル	Organic Letters
巻	14
号	20
DOI	https://doi.org/10.1021/ol3024677
出版ステータス	Published - 2012 10月 19

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

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10.1021/ol3024677

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AU - Hosokawa, Seijiro

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AB - The Kobayashi aldol reaction is one of the most powerful methods to synthesize the polyketide skeleton and has been applied to the total synthesis of natural products. This methodology has been used to construct anti-aldol products, and only a few precedents on the syn-selective Kobayashi aldol reaction are known. A syn-selective Kobayashi aldol reaction by using the E,E-vinylketene silyl N,O-acetal and an excess amount of Lewis acid is presented.

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Syn-selective kobayashi aldol reaction using the E,E-vinylketene silyl N,O -acetal

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