In this study, a series of electrochemically active oligo(ethylene glycol) (OEG) linear-dendrons have been synthesized and grafted onto electrode surfaces by cyclic voltammetry (CV) to improve protein resistance. Dendronized molecules with peripheral carbazole functionality and branching architecture enabled tethering of the poly(ethylene glycol) (PEG) or OEG group with a predictable number of electrochemical reactive groups affecting OEG distribution and orientation. It is possible that ample spacing between the OEG chains affects the intrinsic hydration of these layers and thus surface protein resistance. The films were characterized by CV, surface plasmon resonance (SPR), static contact angle measurements, and atomic force microscopy (AFM). This approach should enable improved nonbiofouling properties on biorelevant electrode surfaces (metal or metal oxides) by potentiostatic or potentiodynamic electrochemical methods, providing an alternative to the self-assembled monolayer (SAM) approach for anchoring PEG layers.
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