Synthesis of cationic aminolipids and characteristic of cationic liposome

Yosuke Obata*, Shinii Takeoka

*この研究の対応する著者

研究成果: Paper査読

抄録

The development of new gene delivery technologies is required using novel nonviral lipid. In this paper, we synthesized new cationic lipids from amino acids. Our synthesized cationic lipids have glutamic acid skeleton at hydrophobic part and have amino acid such as lysine and histidine, arginine at hydrophilic part. We investigated physicochemical properties of the lipid assemblies. This synthesized lipids formed vesicle in water. We reported the synthetic methods of new cationic lipids and evaluated characteristics of cationic lipids with TEM and fluorescent-labeled method. Furthermore, we preparated cationic liposome using the synthesized amino lipids as a part of membrane components.

本文言語English
ページ数1
出版ステータスPublished - 2005 12月 1
イベント54th SPSJ Annual Meeting 2005 - Yokohama, Japan
継続期間: 2005 5月 252005 5月 27

Conference

Conference54th SPSJ Annual Meeting 2005
国/地域Japan
CityYokohama
Period05/5/2505/5/27

ASJC Scopus subject areas

  • 工学一般

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