TY - JOUR
T1 - Synthesis of Hexameric Manganese Porphyrin as an SOD Mimic and SOD Activity
AU - Yuasa, Makoto
AU - Oyaizu, Kenichi
AU - Hanyuu, Yukihiro
AU - Hayashi, Takamitsu
AU - Yamaguchi, Aritomo
PY - 2005
Y1 - 2005
N2 - Free radicals and related species derived from O2 such as superoxide anion radical (O2-·), hydrogen peroxide (H2O2), hydroxyl radical (·OH) and peroxynitrite ion (ONOO-) are often generated in organisms with possibly consequent diseases. The enzyme, superoxide dismutase (SOD), catalyzes the reaction which eliminates O2-· As models of SOD, manganese porphyrins such as [meso-tetrakis(N-methylpyridinium-4-yl)porphyrinato] manganese(III) (MnT4MPyP) have been investigated. However, the half-life of any one of these in the blood is usually quite short. We undertook the design of a novel hexameric manganese porphyrin (HexMnP) capable of remaining for a prolonged period in the blood. The SOD activity of HexMnP (IC50 = 2.1±0.7 μM) was found to be somewhat less than that of MnT4MPyP (IC50 = 0.71 μM), but to exceed that of reconstituted hemoglobin (MnT4MPyP-Hb) (IC50 = 2.0 μM) prepared in a previous study. HexMnP proved to be an effective SOD model in which HexMnP had the capacity to remain over a long period of time in the blood, owing to its molecular diameter of more than 80Å.
AB - Free radicals and related species derived from O2 such as superoxide anion radical (O2-·), hydrogen peroxide (H2O2), hydroxyl radical (·OH) and peroxynitrite ion (ONOO-) are often generated in organisms with possibly consequent diseases. The enzyme, superoxide dismutase (SOD), catalyzes the reaction which eliminates O2-· As models of SOD, manganese porphyrins such as [meso-tetrakis(N-methylpyridinium-4-yl)porphyrinato] manganese(III) (MnT4MPyP) have been investigated. However, the half-life of any one of these in the blood is usually quite short. We undertook the design of a novel hexameric manganese porphyrin (HexMnP) capable of remaining for a prolonged period in the blood. The SOD activity of HexMnP (IC50 = 2.1±0.7 μM) was found to be somewhat less than that of MnT4MPyP (IC50 = 0.71 μM), but to exceed that of reconstituted hemoglobin (MnT4MPyP-Hb) (IC50 = 2.0 μM) prepared in a previous study. HexMnP proved to be an effective SOD model in which HexMnP had the capacity to remain over a long period of time in the blood, owing to its molecular diameter of more than 80Å.
KW - cationic manganese porphyrin
KW - hexameric manganese porphyrin
KW - superoxide dismutase mimic
UR - http://www.scopus.com/inward/record.url?scp=34247855385&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34247855385&partnerID=8YFLogxK
U2 - 10.5650/jos.54.513
DO - 10.5650/jos.54.513
M3 - Article
AN - SCOPUS:34247855385
SN - 1345-8957
VL - 54
SP - 513
EP - 518
JO - Journal of oleo science
JF - Journal of oleo science
IS - 9
ER -