@article{d973f114e1d14407b92332d650581929,
title = "Synthesis of multiply arylated pyridines",
abstract = "We have achieved a synthesis of multiply arylated pyridines by using a [4 + 2] cycloaddition of 2,4-diaryl-5-chloroxazoles and cinnamic acids as a key reaction. The resulting hydroxytriarylpyridines can be derivatized into triarylpyridines, tetraarylpyridines and pentaarylpyridines by sequential cross-couplings. This synthetic method allows for facile and rapid access to highly arylated pyridines with different aryl substituents.",
keywords = "Cross-coupling, Heterocyclic compound, Palladium, Pyridine, Ring transformation",
author = "Takashi Asako and Wakana Hayashi and Kazuma Amaike and Shin Suzuki and Kenichiro Itami and Kei Muto and Junichiro Yamaguchi",
note = "Funding Information: This work was supported by JSPS KAKENHI Grant Nos. JP16H01011, JP16H01140, JP16H04148 (to J.Y.), JP16H07291 (to K.M), the ERATO program from JST (K.I.), and a JSPS research fellowship for young scientists (to K.A. and S.S). We thank Dr. Yasutomo Segawa for assistance with X-ray crystallography. We also thank Dr. Yoshihiro Ishihara (Vertex Pharmaceuticals) for fruitful discussion and critical comments. ITbM is supported by the World Premier International Research Center (WPI) Initiative, Japan. Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",
year = "2017",
doi = "10.1016/j.tet.2017.03.095",
language = "English",
volume = "73",
pages = "3669--3676",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "26",
}