Synthetic studies on taxol: Highly stereoselective construction of the taxol C-ring via SN2′ reduction of an allylic phosphonium salt

Masayuki Utsugi; Masayuki Miyano; Masahisa Nakada

doi:10.1021/ol0608606

Synthetic studies on taxol: Highly stereoselective construction of the taxol C-ring via S_N2′ reduction of an allylic phosphonium salt

Masayuki Utsugi, Masayuki Miyano, Masahisa Nakada^*

^*この研究の対応する著者

先進理工学部

研究成果: Article › 査読

13 被引用数 (Scopus)

抄録

The highly stereoselective construction of the C3 stereogenic center of the taxol C-ring is described. The trans isomer at the C3-C8 position of the taxol C-ring, which is required for the total synthesis, as well as its diastereomeric cis isomer were successfully synthesized with highly diastereoselective S _N2′ reduction of the allylic phosphonium salts.

本文言語	English
ページ（範囲）	2973-2976
ページ数	4
ジャーナル	Organic Letters
巻	8
号	14
DOI	https://doi.org/10.1021/ol0608606
出版ステータス	Published - 2006 7月 6

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

文献へのアクセス

10.1021/ol0608606

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引用スタイル

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