@article{7f70656c7bc74f8aa997c63df1516c66,
title = "The first total synthesis and structural determination of antibiotics K1115 B1s (alnumycins)",
abstract = "K1115 B1, isolated from the broth of Streptomyces species, was found to be a mixture of stereoisomers. Authors synthesized all stereoisomers of K1115 B1 by convergent synthesis coupling a rhamnose derivative, an isobenzofuranone, and a chiral tetraol. Comparison of 1H NMR spectra and optical rotations made it clear that the absolute structures of K1115 B 1α (the major isomer) and K1115 B1β (the minor isomer) were (1R, 17S)- and (1R, 17R)-configurations, respectively. The optical rotations of the stereoisomers revealed that alnumycin, reported as the identical structure with K1115 B1, might be another mixture of stereoisomers.",
keywords = "Alnumycin, BE-41956A, K1115 B, Michael-Dieckmann type condensation, Structural determination, Total synthesis",
author = "Kuniaki Tatsuta and Sonoko Tokishita and Tomohiro Fukuda and Takaaki Kano and Tadaaki Komiya and Seijiro Hosokawa",
note = "Funding Information: Authors thank Eisai Co., Ltd for giving NMR spectra of the natural product and Streptomyces griseorubiginosus (Mer-K1115) strain. Authors also thank Dr. Yoshikazu Takahashi of Microbial Chemistry Research Center for fermentation of the strain. Additionally, authors thanks Mr. Hiroomi Ogino, Mr. Tatsuya Nakamura, and Dr. Yoshikazu Suzuki for the preliminary studies. Authors are grateful for financial support to GCOE program {\textquoteleft}Center for Practical Chemical Wisdom{\textquoteright}, and the Ministry of Education, Culture, Sports, Science and Technology (MEXT). ",
year = "2011",
month = mar,
day = "2",
doi = "10.1016/j.tetlet.2010.12.061",
language = "English",
volume = "52",
pages = "983--986",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd",
number = "9",
}