The G protein-coupled receptor family C group 6 subtype a (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells

Manami Oya; Tetsuya Kitaguchi; Ramona Pais; Frank Reimann; Fiona Gribble; Takashi Tsuboi

doi:10.1074/jbc.M112.402677

The G protein-coupled receptor family C group 6 subtype a (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells

Manami Oya, Tetsuya Kitaguchi, Ramona Pais, Frank Reimann, Fiona Gribble, Takashi Tsuboi^*

^*この研究の対応する著者

重点領域研究機構

研究成果: Article › 査読

119 被引用数 (Scopus)

抄録

Background: The molecular mechanisms underlying GLP-1 secretion induced by amino acids from intestinal L cells are not fully understood. Results: The L-amino acid-sensing GPRC6A receptor is expressed in the clonal L cell GLUTag. Activation of GPRC6A by L-ornithine evoked GLP-1 secretion. Conclusion: GLUTag cells respond to amino acids via the GPRC6A receptor. Significance: A new pathway for GLP-1 secretion induced by amino acids in GLUTag cells was identified.

本文言語	English
ページ（範囲）	4513-4521
ページ数	9
ジャーナル	Journal of Biological Chemistry
巻	288
号	7
DOI	https://doi.org/10.1074/jbc.M112.402677
出版ステータス	Published - 2013 2月 15

ASJC Scopus subject areas

生化学
細胞生物学
分子生物学

文献へのアクセス

10.1074/jbc.M112.402677

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Link to publication in Scopus

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引用スタイル

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abstract = "Background: The molecular mechanisms underlying GLP-1 secretion induced by amino acids from intestinal L cells are not fully understood. Results: The L-amino acid-sensing GPRC6A receptor is expressed in the clonal L cell GLUTag. Activation of GPRC6A by L-ornithine evoked GLP-1 secretion. Conclusion: GLUTag cells respond to amino acids via the GPRC6A receptor. Significance: A new pathway for GLP-1 secretion induced by amino acids in GLUTag cells was identified.",

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AU - Oya, Manami

AU - Kitaguchi, Tetsuya

AU - Pais, Ramona

AU - Reimann, Frank

AU - Gribble, Fiona

AU - Tsuboi, Takashi

PY - 2013/2/15

Y1 - 2013/2/15

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AB - Background: The molecular mechanisms underlying GLP-1 secretion induced by amino acids from intestinal L cells are not fully understood. Results: The L-amino acid-sensing GPRC6A receptor is expressed in the clonal L cell GLUTag. Activation of GPRC6A by L-ornithine evoked GLP-1 secretion. Conclusion: GLUTag cells respond to amino acids via the GPRC6A receptor. Significance: A new pathway for GLP-1 secretion induced by amino acids in GLUTag cells was identified.

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