The main factor of the decrease in activity of luciferase on the Si surface

Katsuhiko Nishiyama; Takanobu Watanabe; Tadatsugu Hoshino; Iwao Ohdomari

doi:10.1016/j.cplett.2008.01.040

The main factor of the decrease in activity of luciferase on the Si surface

Katsuhiko Nishiyama^*, Takanobu Watanabe, Tadatsugu Hoshino, Iwao Ohdomari

^*この研究の対応する著者

基幹理工学部

研究成果: Article › 査読

2 被引用数 (Scopus)

抄録

The interactions between the luciferase surface area around the active site and the Si surface were estimated by molecular dynamics simulations. The results show that the luciferase surface area around the active site is more unstable than the luciferase surface area with relatively high hydrophobicity when luciferase adsorbs on the Si surface. The main factor of the decrease in activity of luciferase on the Si surface would be adsorption-induced structural changes in active site. Si surface should be designed focusing on structural changes in active site.

本文言語	English
ページ（範囲）	279-282
ページ数	4
ジャーナル	Chemical Physics Letters
巻	453
号	4-6
DOI	https://doi.org/10.1016/j.cplett.2008.01.040
出版ステータス	Published - 2008 3月 3

ASJC Scopus subject areas

物理学および天文学（全般）
物理化学および理論化学

文献へのアクセス

10.1016/j.cplett.2008.01.040

他のファイルとリンク

引用スタイル

@article{340373232e534802a8c4ec4c3ef57bb9,

title = "The main factor of the decrease in activity of luciferase on the Si surface",

abstract = "The interactions between the luciferase surface area around the active site and the Si surface were estimated by molecular dynamics simulations. The results show that the luciferase surface area around the active site is more unstable than the luciferase surface area with relatively high hydrophobicity when luciferase adsorbs on the Si surface. The main factor of the decrease in activity of luciferase on the Si surface would be adsorption-induced structural changes in active site. Si surface should be designed focusing on structural changes in active site.",

author = "Katsuhiko Nishiyama and Takanobu Watanabe and Tadatsugu Hoshino and Iwao Ohdomari",

note = "Funding Information: This study is supported by a Grant-in-Aid for Center of Excellence (COE) Research from the Ministry of Education, Culture, Sports, Science and Technology, by a Grant for the Promotion of the Advancement of Education and Research in Graduate Schools from the Promotion and Mutual Aid Corporation for Private Schools of Japan, and by JST-PRESTO.",

year = "2008",

month = mar,

day = "3",

doi = "10.1016/j.cplett.2008.01.040",

language = "English",

volume = "453",

pages = "279--282",

journal = "Chemical Physics Letters",

issn = "0009-2614",

publisher = "Elsevier",

number = "4-6",

}

TY - JOUR

T1 - The main factor of the decrease in activity of luciferase on the Si surface

AU - Nishiyama, Katsuhiko

AU - Watanabe, Takanobu

AU - Hoshino, Tadatsugu

AU - Ohdomari, Iwao

N1 - Funding Information: This study is supported by a Grant-in-Aid for Center of Excellence (COE) Research from the Ministry of Education, Culture, Sports, Science and Technology, by a Grant for the Promotion of the Advancement of Education and Research in Graduate Schools from the Promotion and Mutual Aid Corporation for Private Schools of Japan, and by JST-PRESTO.

PY - 2008/3/3

Y1 - 2008/3/3

N2 - The interactions between the luciferase surface area around the active site and the Si surface were estimated by molecular dynamics simulations. The results show that the luciferase surface area around the active site is more unstable than the luciferase surface area with relatively high hydrophobicity when luciferase adsorbs on the Si surface. The main factor of the decrease in activity of luciferase on the Si surface would be adsorption-induced structural changes in active site. Si surface should be designed focusing on structural changes in active site.

AB - The interactions between the luciferase surface area around the active site and the Si surface were estimated by molecular dynamics simulations. The results show that the luciferase surface area around the active site is more unstable than the luciferase surface area with relatively high hydrophobicity when luciferase adsorbs on the Si surface. The main factor of the decrease in activity of luciferase on the Si surface would be adsorption-induced structural changes in active site. Si surface should be designed focusing on structural changes in active site.

UR - http://www.scopus.com/inward/record.url?scp=44549083749&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44549083749&partnerID=8YFLogxK

U2 - 10.1016/j.cplett.2008.01.040

DO - 10.1016/j.cplett.2008.01.040

M3 - Article

AN - SCOPUS:44549083749

SN - 0009-2614

VL - 453

SP - 279

EP - 282

JO - Chemical Physics Letters

JF - Chemical Physics Letters

IS - 4-6

ER -

The main factor of the decrease in activity of luciferase on the Si surface

抄録

ASJC Scopus subject areas

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル