TY - JOUR
T1 - The role of 8-oxoguanine DNA glycosylase-1 in inflammation
AU - Ba, Xueqing
AU - Aguilera-Aguirre, Leopoldo
AU - Rashid, Qura Tul Ain Nmi
AU - Bacsi, Attila
AU - Radak, Zsolt
AU - Sur, Sanjiv
AU - Hosoki, Koa
AU - Hegde, Muralidhar L.
AU - Boldogh, Istvan
N1 - Publisher Copyright:
© 2014 by the authors; licensee MDPI, Basel, Switzerland.
PY - 2014/9/23
Y1 - 2014/9/23
N2 - Many, if not all, environmental pollutants/chemicals and infectious agents increase intracellular levels of reactive oxygen species (ROS) at the site of exposure. ROS not only function as intracellular signaling entities, but also induce damage to cellular molecules including DNA. Among the several dozen ROS-induced DNA base lesions generated in the genome, 8-oxo-7,8-dihydroguanine (8-oxoG) is one of the most abundant because of guanine's lowest redox potential among DNA bases. In mammalian cells, 8-oxoG is repaired by the 8-oxoguanine DNA glycosylase-1 (OGG1)-initiated DNA base excision repair pathway (OGG1–BER). Accumulation of 8-oxoG in DNA has traditionally been associated with mutagenesis, as well as various human diseases and aging processes, while the free 8-oxoG base in body fluids is one of the best biomarkers of ongoing pathophysiological processes. In this review, we discuss the biological significance of the 8-oxoG base and particularly the role of OGG1–BER in the activation of small GTPases and changes in gene expression, including those that regulate pro-inflammatory chemokines/cytokines and cause inflammation.
AB - Many, if not all, environmental pollutants/chemicals and infectious agents increase intracellular levels of reactive oxygen species (ROS) at the site of exposure. ROS not only function as intracellular signaling entities, but also induce damage to cellular molecules including DNA. Among the several dozen ROS-induced DNA base lesions generated in the genome, 8-oxo-7,8-dihydroguanine (8-oxoG) is one of the most abundant because of guanine's lowest redox potential among DNA bases. In mammalian cells, 8-oxoG is repaired by the 8-oxoguanine DNA glycosylase-1 (OGG1)-initiated DNA base excision repair pathway (OGG1–BER). Accumulation of 8-oxoG in DNA has traditionally been associated with mutagenesis, as well as various human diseases and aging processes, while the free 8-oxoG base in body fluids is one of the best biomarkers of ongoing pathophysiological processes. In this review, we discuss the biological significance of the 8-oxoG base and particularly the role of OGG1–BER in the activation of small GTPases and changes in gene expression, including those that regulate pro-inflammatory chemokines/cytokines and cause inflammation.
KW - 8-oxoG base
KW - DNA base excision repair
KW - Inflammation
KW - OGG1
KW - Small GTPases
UR - http://www.scopus.com/inward/record.url?scp=84907867357&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907867357&partnerID=8YFLogxK
U2 - 10.3390/ijms150916975
DO - 10.3390/ijms150916975
M3 - Review article
C2 - 25250913
AN - SCOPUS:84907867357
SN - 1661-6596
VL - 15
SP - 16975
EP - 16997
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 9
ER -