The roles of microRNA in redox metabolism and exercise-mediated adaptation

Ferenc Torma; Zoltan Gombos; Matyas Jokai; Istvan Berkes; Masaki Takeda; Tatsuya Mimura; Zsolt Radak; Ferenc Gyori

doi:10.1016/j.jshs.2020.03.004

The roles of microRNA in redox metabolism and exercise-mediated adaptation

Ferenc Torma, Zoltan Gombos, Matyas Jokai, Istvan Berkes, Masaki Takeda, Tatsuya Mimura, Zsolt Radak^*, Ferenc Gyori

^*この研究の対応する著者

大学院スポーツ科学研究科

研究成果: Review article › 査読

18 被引用数 (Scopus)

抄録

MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage caused by reactive oxygen species, and they are active players in redox homeostasis. Increased mitochondrial biogenesis, function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise. In the present review, we highlight some of the redox-sensitive regulatory roles of miRs.

本文言語	English
ページ（範囲）	405-414
ページ数	10
ジャーナル	Journal of Sport and Health Science
巻	9
号	5
DOI	https://doi.org/10.1016/j.jshs.2020.03.004
出版ステータス	Published - 2020 9月

ASJC Scopus subject areas

整形外科およびスポーツ医学
理学療法、スポーツ療法とリハビリテーション

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10.1016/j.jshs.2020.03.004

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title = "The roles of microRNA in redox metabolism and exercise-mediated adaptation",

abstract = "MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage caused by reactive oxygen species, and they are active players in redox homeostasis. Increased mitochondrial biogenesis, function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise. In the present review, we highlight some of the redox-sensitive regulatory roles of miRs.",

keywords = "Adaptation, Exercise, MicroRNA, Oxidative damage, Reactive oxygen species, Redox regulation",

author = "Ferenc Torma and Zoltan Gombos and Matyas Jokai and Istvan Berkes and Masaki Takeda and Tatsuya Mimura and Zsolt Radak and Ferenc Gyori",

note = "Funding Information: This study was supported by OTKA (112810) and National Excellence Program (126823) Grants awarded to ZR. Publisher Copyright: {\textcopyright} 2020",

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AU - Torma, Ferenc

AU - Gombos, Zoltan

AU - Jokai, Matyas

AU - Berkes, Istvan

AU - Takeda, Masaki

AU - Mimura, Tatsuya

AU - Radak, Zsolt

AU - Gyori, Ferenc

PY - 2020/9

Y1 - 2020/9

N2 - MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage caused by reactive oxygen species, and they are active players in redox homeostasis. Increased mitochondrial biogenesis, function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise. In the present review, we highlight some of the redox-sensitive regulatory roles of miRs.

AB - MicroRNAs (miRs) are small regulatory RNA transcripts capable of post-transcriptional silencing of mRNA messages by entering a cellular bimolecular apparatus called RNA-induced silencing complex. miRs are involved in the regulation of cellular processes producing, eliminating or repairing the damage caused by reactive oxygen species, and they are active players in redox homeostasis. Increased mitochondrial biogenesis, function and hypertrophy of skeletal muscle are important adaptive responses to regular exercise. In the present review, we highlight some of the redox-sensitive regulatory roles of miRs.

KW - Adaptation

KW - Exercise

KW - MicroRNA

KW - Oxidative damage

KW - Reactive oxygen species

KW - Redox regulation

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The roles of microRNA in redox metabolism and exercise-mediated adaptation

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ASJC Scopus subject areas

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