The systemic role of SIRT1 in exercise mediated adaptation

Zsolt Radak*, Katsuhiko Suzuki, Aniko Posa, Zita Petrovszky, Erika Koltai, Istvan Boldogh


研究成果: Review article査読

42 被引用数 (Scopus)


Cellular energy demands are readily changed during physical exercise resulting in adaptive responses by signaling proteins of metabolic processes, including the NAD+ dependent lysine deacetylase SIRT1. Regular exercise results in systemic adaptation that restores the level of SIRT1 in the kidney, liver, and brain in patients with neurodegenerative diseases, and thereby normalizes cellular metabolic processes to attenuate the severity of these diseases. In skeletal muscle, over-expression of SIRT1 results in enhanced numbers of myonuclei improves the repair process after injury and is actively involved in muscle hypertrophy by up-regulating anabolic and downregulating catabolic processes. The present review discusses the different views of SIRT1 dependent deacetylation of PGC-α.

ジャーナルRedox Biology
出版ステータスPublished - 2020 8月

ASJC Scopus subject areas

  • 有機化学
  • 臨床生化学


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