An unusual penta-peptide nanotube was synthesized by a solid-phase method using Fmoc chemistry. This nanotube consists of the natural homo-L-amino acid sequence (cyclo[-(L-Gln)5]), which is different from the already-known DL-peptide nanotubes having an even number of residues. We also observed the morphology by atomic force microscope (AFM) and found meandering tubular structures on the substrate. This result is consistent with our ab initio energy calculations, which show that the penta-peptide nanorings stabilize by breaking the C5 symmetry and stack themselves to form a meandering nanotube through the inter-ring hydrogen bonds.
|Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers
|Published - 2003 2月
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