TY - JOUR
T1 - Thioporidiols a and b
T2 - Two new sulfur compounds discovered by molybdenum-catalyzed oxidation screening from trichoderma polypori FKI-7382
AU - Matsuo, Hirotaka
AU - Noguchi, Yoshihiko
AU - Miyano, Rei
AU - Higo, Mayuka
AU - Nonaka, Kenichi
AU - Sunazuka, Toshiaki
AU - Takahashi, Yōko
AU - Ōmura, Satoshi
AU - Nakashima, Takuji
N1 - Funding Information:
Funding: This study was supported by a Sasakawa Scientific Research Grant from the Japan Science Society to H. Matsuo (2019-3025), a JSPS KAKENHI for Young Scientists (grant no. JP19K15758) to H. Matsuo, and a Kitasato University Research Grant for Young Researchers, awarded to H. Matsuo.
Funding Information:
Acknowledgments: This study was supported by the Institute for Fermentation, Osaka, Japan. We thank Ms. Noriko Sato (School of Pharmacy, Kitasato University) for the measurements of NMR.
Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/5
Y1 - 2020/5
N2 - Two new sulfur compounds, designated thioporidiol A (1) and B (2), were discovered by the MoS-screening program from a culture broth of Trichoderma polypori FKI-7382. The structures of 1 and 2 were determined as C13 lipid structures with an N-acetylcysteine moiety. The relative configuration at the C-5 and C-6 position of 1 was determined by the derivatives of α-methoxy-α-phenylacetic acid diesters, and the absolute configuration of the N-acetylcysteine moiety was determined by advanced Marfey’s analysis. Compounds 1 and 2 were evaluated for anti-microbial, cytotoxic and anti-malarial activities. Compound 2 exhibited anti-microbial activity against Candida albicans ATCC 64548.
AB - Two new sulfur compounds, designated thioporidiol A (1) and B (2), were discovered by the MoS-screening program from a culture broth of Trichoderma polypori FKI-7382. The structures of 1 and 2 were determined as C13 lipid structures with an N-acetylcysteine moiety. The relative configuration at the C-5 and C-6 position of 1 was determined by the derivatives of α-methoxy-α-phenylacetic acid diesters, and the absolute configuration of the N-acetylcysteine moiety was determined by advanced Marfey’s analysis. Compounds 1 and 2 were evaluated for anti-microbial, cytotoxic and anti-malarial activities. Compound 2 exhibited anti-microbial activity against Candida albicans ATCC 64548.
KW - Anti-microbial activity
KW - MoS-screening
KW - N-acetylcysteine
KW - Sulfur compound
KW - Thioporidiol A and B
KW - Trichoderma polypori
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U2 - 10.3390/antibiotics9050236
DO - 10.3390/antibiotics9050236
M3 - Article
AN - SCOPUS:85085292440
SN - 2079-6382
VL - 9
JO - Antibiotics
JF - Antibiotics
IS - 5
M1 - 236
ER -