Three-dimensional simulation of liver reproduction after hepatic lobectomy

We have constructed the 3D liver model consisting of numerous cubic compartments from slices of structural data measured using x-ray CT and simulated processes of liver reproductions after hepatic lobectomies, which are operations to remove intrahepatic tumors, considering structural and functional characters of livers. We took account of some factors affecting reproductions; 3D distributions of intrahepatic functional conditions, accelerations of reproducing activities around the excised surfaces, and functional compensations between lobes. The effect of these factors in each compartment were calculated from structural data according to the relative position of the compartment in the model. Compartments were duplicated in proportion to the parameters. Reproducing processes of liver tissues and changes of the appearance were simulated. The same excision as a certain clinical case was assigned to the model. Simulations were passed on changing values of parameters to modify the model accordingly. The result was compared with the clinical case.