Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue

Shijun Wen; Krystle L. Carey; Yoichi Nakao; Nobuhiro Fusetani; Graham Packham; A. Ganesan

doi:10.1021/ol070046y

Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue

Shijun Wen, Krystle L. Carey, Yoichi Nakao, Nobuhiro Fusetani, Graham Packham, A. Ganesan^*

^*この研究の対応する著者

研究成果: Article › 査読

55 被引用数 (Scopus)

抄録

(Chemical Equation Presented) The unprecedented diastereoselective Mannich reaction of a Z-allylsulfoximine was a key step in the total synthesis of the marine natural products azumamide A and E, and an unnatural analogue. Their relative potency as histone deacetylase inhibitors was evaluated and found to correlate with predicted zinc-binding affinity.

本文言語	English
ページ（範囲）	1105-1108
ページ数	4
ジャーナル	Organic Letters
巻	9
号	6
DOI	https://doi.org/10.1021/ol070046y
出版ステータス	Published - 2007 3月 15
外部発表	はい

ASJC Scopus subject areas

生化学
物理化学および理論化学
有機化学

文献へのアクセス

10.1021/ol070046y

他のファイルとリンク

フィンガープリント

「Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

@article{a3d963f594b744939241aa620e75de20,

title = "Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue",

abstract = "(Chemical Equation Presented) The unprecedented diastereoselective Mannich reaction of a Z-allylsulfoximine was a key step in the total synthesis of the marine natural products azumamide A and E, and an unnatural analogue. Their relative potency as histone deacetylase inhibitors was evaluated and found to correlate with predicted zinc-binding affinity.",

author = "Shijun Wen and Carey, {Krystle L.} and Yoichi Nakao and Nobuhiro Fusetani and Graham Packham and A. Ganesan",

year = "2007",

month = mar,

day = "15",

doi = "10.1021/ol070046y",

language = "English",

volume = "9",

pages = "1105--1108",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "6",

}

TY - JOUR

T1 - Total synthesis of azumamide A and azumamide E, evaluation as histone deacetylase inhibitors, and design of a more potent analogue

AU - Wen, Shijun

AU - Carey, Krystle L.

AU - Nakao, Yoichi

AU - Fusetani, Nobuhiro

AU - Packham, Graham

AU - Ganesan, A.

PY - 2007/3/15

Y1 - 2007/3/15

N2 - (Chemical Equation Presented) The unprecedented diastereoselective Mannich reaction of a Z-allylsulfoximine was a key step in the total synthesis of the marine natural products azumamide A and E, and an unnatural analogue. Their relative potency as histone deacetylase inhibitors was evaluated and found to correlate with predicted zinc-binding affinity.

AB - (Chemical Equation Presented) The unprecedented diastereoselective Mannich reaction of a Z-allylsulfoximine was a key step in the total synthesis of the marine natural products azumamide A and E, and an unnatural analogue. Their relative potency as histone deacetylase inhibitors was evaluated and found to correlate with predicted zinc-binding affinity.

UR - http://www.scopus.com/inward/record.url?scp=33947586979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33947586979&partnerID=8YFLogxK

U2 - 10.1021/ol070046y

DO - 10.1021/ol070046y

M3 - Article

C2 - 17311393

AN - SCOPUS:33947586979

SN - 1523-7060

VL - 9

SP - 1105

EP - 1108

JO - Organic Letters

JF - Organic Letters

IS - 6

ER -