Total synthesis of PDIM A

Tatsuya Nakamura; Hanae Nakagome; Shoichiro Sano; Tomoko Sadayuki; Seijiro Hosokawa

doi:10.1246/cl.160152

Total synthesis of PDIM A

Tatsuya Nakamura, Hanae Nakagome, Shoichiro Sano, Tomoko Sadayuki, Seijiro Hosokawa^*

^*この研究の対応する著者

研究成果: Article › 査読

5 被引用数 (Scopus)

抄録

Total synthesis of phthiocerol dimycocerosate A (PDIM A), a virulent factor of Mycobacterium tuberculosis, has been achieved. Phthiocerol, a component of PDIM A, has been synthesized by subsequent epoxide-opening alkylation reactions with arabinose-derived diepoxide. This route is concise and efficient in supplying PDIM A for biological studies.

本文言語	English
ページ（範囲）	550-551
ページ数	2
ジャーナル	Chemistry Letters
巻	45
号	5
DOI	https://doi.org/10.1246/cl.160152
出版ステータス	Published - 2016

ASJC Scopus subject areas

化学 (全般)

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.1246/cl.160152

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abstract = "Total synthesis of phthiocerol dimycocerosate A (PDIM A), a virulent factor of Mycobacterium tuberculosis, has been achieved. Phthiocerol, a component of PDIM A, has been synthesized by subsequent epoxide-opening alkylation reactions with arabinose-derived diepoxide. This route is concise and efficient in supplying PDIM A for biological studies.",

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AU - Nakamura, Tatsuya

AU - Nakagome, Hanae

AU - Sano, Shoichiro

AU - Sadayuki, Tomoko

AU - Hosokawa, Seijiro

PY - 2016

Y1 - 2016

N2 - Total synthesis of phthiocerol dimycocerosate A (PDIM A), a virulent factor of Mycobacterium tuberculosis, has been achieved. Phthiocerol, a component of PDIM A, has been synthesized by subsequent epoxide-opening alkylation reactions with arabinose-derived diepoxide. This route is concise and efficient in supplying PDIM A for biological studies.

AB - Total synthesis of phthiocerol dimycocerosate A (PDIM A), a virulent factor of Mycobacterium tuberculosis, has been achieved. Phthiocerol, a component of PDIM A, has been synthesized by subsequent epoxide-opening alkylation reactions with arabinose-derived diepoxide. This route is concise and efficient in supplying PDIM A for biological studies.

KW - Phthiocerol dimycocerosate A (PDIM A)

KW - Total synthesis

KW - Tuberculosis

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JO - Chemistry Letters

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Total synthesis of PDIM A

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ASJC Scopus subject areas

UN SDG

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