TY - JOUR
T1 - Transcriptional control of the Pgc-1α gene in skeletal muscle in vivo
AU - Yan, Zhen
AU - Li, Ping
AU - Akimoto, Takayuki
PY - 2007/7
Y1 - 2007/7
N2 - Endurance exercise promotes mitochondrial biogenesis in skeletal muscle possibly by inducing peroxisome proliferator-activated receptor γ coactivator 1α gene transcription through activation of the p38 mitogen-activated protein kinase pathway. A novel imaging analysis revealed the importance of activating transcription factor 2 and histone deacetylase 5/myocyte enhancer factor 2 in the regulation of the Pgc-1α gene in skeletal muscle in vivo.
AB - Endurance exercise promotes mitochondrial biogenesis in skeletal muscle possibly by inducing peroxisome proliferator-activated receptor γ coactivator 1α gene transcription through activation of the p38 mitogen-activated protein kinase pathway. A novel imaging analysis revealed the importance of activating transcription factor 2 and histone deacetylase 5/myocyte enhancer factor 2 in the regulation of the Pgc-1α gene in skeletal muscle in vivo.
KW - Exercise
KW - Fiber-type switching
KW - Mitochondrial biogenesis
KW - Peroxisome proliferator-activated receptor γ coactivator 1α
KW - Signal transduction
KW - Skeletal muscle adaptation
UR - http://www.scopus.com/inward/record.url?scp=34447310267&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34447310267&partnerID=8YFLogxK
U2 - 10.1097/JES.0b013e3180a03169
DO - 10.1097/JES.0b013e3180a03169
M3 - Review article
C2 - 17620927
AN - SCOPUS:34447310267
SN - 0091-6331
VL - 35
SP - 97
EP - 101
JO - Exercise and Sport Sciences Reviews
JF - Exercise and Sport Sciences Reviews
IS - 3
ER -