@article{36590b1204f34df98b8fd546f4209c94,
title = "Trierixin, a novel inhibitor of ER stress-induced XBP1 activation from Streptomyces sp. II. Structure elucidation",
abstract = "Trierixin, a new member of the triene-ansamycin group, has been isolated from the fermentation broth of Streptomyces sp. AC654 as an inhibitor of ER stress-induced XBP1 activation. The structure of trierixin was determined on the basis of its spectroscopical and chemical properties. Trierixin possessed a 21-membered macrocyclic lactam, which contains a methylthio-benzenediol structure, and a cyclohexanecarbonylalanine moiety. Trierixin is thus elucidated as 21-thiomethylmycotrienin II.",
keywords = "ER stress, Triene-ansamycin, Trierixin, XBP1",
author = "Yushi Futamura and Etsu Tashiro and Naoka Hironiwa and Jun Kohno and Maki Nishio and Kazutoshi Shindo and Masaya Imoto",
note = "Funding Information: Acknowledgements This study was partly supported by grants from the New Energy and Industrial Technology Development Organization (NEDO) and a grant from Nateglinide Memorial Toyoshima Research and Education Fund of Keio University. Microbial extracts were obtained from The Broth Screening Network organized by Dr. H. Osada (RIKEN).",
year = "2007",
month = sep,
doi = "10.1038/ja.2007.74",
language = "English",
volume = "60",
pages = "582--585",
journal = "Journal of Antibiotics",
issn = "0021-8820",
publisher = "Japan Antibiotics Research Association",
number = "9",
}