TY - JOUR
T1 - Tumor microenvironment-regulated nanoplatforms for the inhibition of tumor growth and metastasis in chemo-immunotherapy
AU - Yu, Xueping
AU - Wang, Xiupeng
AU - Yamazaki, Atsushi
AU - Li, Xia
N1 - Funding Information:
We thank Dr. Yu Sogo and Ms. Hisako Sugino for their discussion and technical assistance. X. P. Yu is grateful for the support of the Japanese Government Scholarship. This work was supported in part by AIST, Japan Society for the Promotion of Science (JSPS, KAKENHI Grant Number 17K01399). This work was supported in part by the NIMS Molecule & Material Synthesis Platform as a program of the “Nanotechnology Platform” of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan. FE-SEM and XPS measurements were performed at the Materials Characterization Central Laboratory, Waseda University. The FE-TEM-EDS measurement was performed at the Kagami Memorial Research Institute for Materials Science and Technology, Waseda University.
Publisher Copyright:
© 2022 The Royal Society of Chemistry
PY - 2022
Y1 - 2022
N2 - Chemotherapy is one of the major clinical anticancer therapies. However, its efficiency is limited by many factors, including the complex tumor microenvironment (TME). Herein, manganese-doped mesoporous silica nanoparticles (MM NPs) were constructed and applied to regulate the TME and enhance the efficiency of the combination of chemotherapy and immunotherapy (chemo-immunotherapy). Notably, the combination of MM NPs, doxorubicin hydrochloride, and immune checkpoint inhibitors enhanced the synergistic efficiency of chemo-immunotherapy in a bilateral animal model, which simultaneously inhibited the growth of primary tumors and distant untreated tumors. Moreover, Mn-doping endowed MSNs with six new regulatory functions for the TME by inducing glutathione depletion, ROS generation, oxygenation, cell-killing effect, immune activation, and degradation promotion. These results demonstrated that MM NPs with TME regulatory functions can potentially improve the efficiency of chemo-immunotherapy.
AB - Chemotherapy is one of the major clinical anticancer therapies. However, its efficiency is limited by many factors, including the complex tumor microenvironment (TME). Herein, manganese-doped mesoporous silica nanoparticles (MM NPs) were constructed and applied to regulate the TME and enhance the efficiency of the combination of chemotherapy and immunotherapy (chemo-immunotherapy). Notably, the combination of MM NPs, doxorubicin hydrochloride, and immune checkpoint inhibitors enhanced the synergistic efficiency of chemo-immunotherapy in a bilateral animal model, which simultaneously inhibited the growth of primary tumors and distant untreated tumors. Moreover, Mn-doping endowed MSNs with six new regulatory functions for the TME by inducing glutathione depletion, ROS generation, oxygenation, cell-killing effect, immune activation, and degradation promotion. These results demonstrated that MM NPs with TME regulatory functions can potentially improve the efficiency of chemo-immunotherapy.
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U2 - 10.1039/d2tb00337f
DO - 10.1039/d2tb00337f
M3 - Article
C2 - 35439801
AN - SCOPUS:85129882355
SN - 2050-7518
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
ER -