TY - JOUR
T1 - Tumor microenvironment-regulated nanoplatforms for the inhibition of tumor growth and metastasis in chemo-immunotherapy
AU - Yu, Xueping
AU - Wang, Xiupeng
AU - Yamazaki, Atsushi
AU - Li, Xia
N1 - Publisher Copyright:
© 2022 The Royal Society of Chemistry.
PY - 2022/3/30
Y1 - 2022/3/30
N2 - Chemotherapy is one of the major clinical anticancer therapies. However, its efficiency is limited by many factors, including the complex tumor microenvironment (TME). Herein, manganese-doped mesoporous silica nanoparticles (MM NPs) were constructed and applied to regulate the TME and enhance the efficiency of the combination of chemotherapy and immunotherapy (chemo-immunotherapy). Notably, the combination of MM NPs, doxorubicin hydrochloride, and immune checkpoint inhibitors enhanced the synergistic efficiency of chemo-immunotherapy in a bilateral animal model, which simultaneously inhibited the growth of primary tumors and distant untreated tumors. Moreover, Mn-doping endowed MSNs with six new regulatory functions for the TME by inducing glutathione depletion, ROS generation, oxygenation, cell-killing effect, immune activation, and degradation promotion. These results demonstrated that MM NPs with TME regulatory functions can potentially improve the efficiency of chemo-immunotherapy.
AB - Chemotherapy is one of the major clinical anticancer therapies. However, its efficiency is limited by many factors, including the complex tumor microenvironment (TME). Herein, manganese-doped mesoporous silica nanoparticles (MM NPs) were constructed and applied to regulate the TME and enhance the efficiency of the combination of chemotherapy and immunotherapy (chemo-immunotherapy). Notably, the combination of MM NPs, doxorubicin hydrochloride, and immune checkpoint inhibitors enhanced the synergistic efficiency of chemo-immunotherapy in a bilateral animal model, which simultaneously inhibited the growth of primary tumors and distant untreated tumors. Moreover, Mn-doping endowed MSNs with six new regulatory functions for the TME by inducing glutathione depletion, ROS generation, oxygenation, cell-killing effect, immune activation, and degradation promotion. These results demonstrated that MM NPs with TME regulatory functions can potentially improve the efficiency of chemo-immunotherapy.
UR - http://www.scopus.com/inward/record.url?scp=85129882355&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85129882355&partnerID=8YFLogxK
U2 - 10.1039/d2tb00337f
DO - 10.1039/d2tb00337f
M3 - Article
C2 - 35439801
AN - SCOPUS:85129882355
SN - 2050-7518
VL - 10
SP - 3637
EP - 3647
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
IS - 19
ER -