抄録
Two previously unreported onnamide analogs, 2Z- and 6Z-onnamides A (1 and 2), were isolated from the marine sponge Theonella conica collected at Amami-Oshima Is., Kagoshima Prefecture, Japan. Structures of compounds 1 and 2 were elucidated by spectral analysis. Structure–activity relationships (SARs) for effects on histone modifications and cytotoxicity against HeLa and P388 cells were characterized. The geometry in the polyene systems of onnamides affected the histone modification levels and cytotoxicity.
本文言語 | English |
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論文番号 | 2524 |
ジャーナル | Molecules |
巻 | 28 |
号 | 6 |
DOI | |
出版ステータス | Published - 2023 3月 |
ASJC Scopus subject areas
- 分析化学
- 化学(その他)
- 分子医療
- 薬科学
- 創薬
- 物理化学および理論化学
- 有機化学