Two osteoclastic markers expressed in multinucleate osteoclasts of goldfish scales

Kyoichi Azuma, Masaki Kobayashi, Masahisa Nakamura*, Nobuo Suzuki, Sayaka Yashima, Shawichi Iwamuro, Mika Ikegame, Toshio Yamamoto, Atsuhiko Hattori


    研究成果: Article査読

    44 被引用数 (Scopus)


    Complementary DNAs encoding two major osteoclastic markers, tartrate-resistant acid phosphatase (TRAP) and cathepsin K (Cath K) were cloned from the scales of a teleost, the goldfish. This is the first report of the full coding sequence of TRAP and Cath K molecules in fish. In the goldfish scale both TRAP and Cath K mRNAs were expressed in the multinucleate osteoclasts, which showed large numbers of mitochondria and lysosomes, and a well developed ruffled border. These characteristic features of osteoclasts in the scales are similar to those in mammals. Most teleosts use the scale as an internal calcium reservoir during the reproductive season. The expression of TRAP and Cath K mRNAs in the scale significantly increased in April, which is a reproductive season, compared with that in October, a non-reproductive season. Thus, both of these molecular markers should be useful for the study of osteoclasts in the teleost scale.

    ジャーナルBiochemical and Biophysical Research Communications
    出版ステータスPublished - 2007 10月 26

    ASJC Scopus subject areas

    • 生化学
    • 生物理学
    • 分子生物学


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