@article{a1f9bf44cc494c77abccfd5f7984608d,
title = "YCM1008A, a novel Ca2+-signaling inhibitor, produced by Fusarium sp. YCM1008",
abstract = "In the course of screening for drugs that suppress the Ca 2+-mediated growth inhibition in a yeast mutant, we found that the metabolite of Fusarium sp. strain YCM1008 inhibited Ca2+-signaling. A novel pyranopyridone, YCM1008A was isolated from the fermentation broth using HLB column chromatography followed by HPLC, and the structure was elucidated by spectral analysis. YCM1008A suppressed Ca2+-induced growth inhibition of the Saccharomyces cerevisiae (Δzds1Δsyr1) mutant.",
keywords = "Ca-signaling, Fusarium, Pyrano-pyridone, YCM1008A, Yeast",
author = "Fumito Koizumi and Naomi Fukumitsu and Jinrong Zhao and Ruthada Chanklan and Tokichi Miyakawa and Shoko Kawahara and Shin Iwamoto and Makoto Suzuki and Shingo Kakita and Rahayu, {Endang S.} and Seijiro Hosokawa and Kuniaki Tatsuta and Michio Ichimura",
note = "Copyright: Copyright 2009 Elsevier B.V., All rights reserved.",
year = "2007",
month = jul,
doi = "10.1038/ja.2007.58",
language = "English",
volume = "60",
pages = "455--458",
journal = "Journal of Antibiotics",
issn = "0021-8820",
publisher = "Japan Antibiotics Research Association",
number = "7",
}