Ytterbium-catalyzed synthesis of dihydropyridines

Shunsuke Sueki; Ryo Takei; Junya Abe; Isao Shimizu

doi:10.1016/j.tetlet.2011.06.070

Ytterbium-catalyzed synthesis of dihydropyridines

Shunsuke Sueki, Ryo Takei, Junya Abe, Isao Shimizu^*

^*この研究の対応する著者

早稲田大学

研究成果: Article › 査読

18 被引用数 (Scopus)

抄録

The reaction of anilines, benzaldehydes, and ethyl 3,3-diethoxypropionate in the presence of Yb(OTf)₃ proceeded under mild reaction conditions to give dihydropyridines (DHPs). We have found that the reaction depended on the solvent and the DHPs were obtained selectively in 1,4-dioxane as a solvent. Various 2,6-unsubstituted DHPs were synthesized in one pot in satisfactory yields.

本文言語	English
ページ（範囲）	4473-4477
ページ数	5
ジャーナル	Tetrahedron Letters
巻	52
号	34
DOI	https://doi.org/10.1016/j.tetlet.2011.06.070
出版ステータス	Published - 2011 8月 24

ASJC Scopus subject areas

生化学
有機化学
創薬

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10.1016/j.tetlet.2011.06.070

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abstract = "The reaction of anilines, benzaldehydes, and ethyl 3,3-diethoxypropionate in the presence of Yb(OTf)3 proceeded under mild reaction conditions to give dihydropyridines (DHPs). We have found that the reaction depended on the solvent and the DHPs were obtained selectively in 1,4-dioxane as a solvent. Various 2,6-unsubstituted DHPs were synthesized in one pot in satisfactory yields.",

keywords = "2,6-Unsubstituted dihydropyridine, DHP, Multi-component coupling reaction, Ytterbium catalyst",

author = "Shunsuke Sueki and Ryo Takei and Junya Abe and Isao Shimizu",

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doi = "10.1016/j.tetlet.2011.06.070",

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T1 - Ytterbium-catalyzed synthesis of dihydropyridines

AU - Sueki, Shunsuke

AU - Takei, Ryo

AU - Abe, Junya

AU - Shimizu, Isao

PY - 2011/8/24

Y1 - 2011/8/24

N2 - The reaction of anilines, benzaldehydes, and ethyl 3,3-diethoxypropionate in the presence of Yb(OTf)3 proceeded under mild reaction conditions to give dihydropyridines (DHPs). We have found that the reaction depended on the solvent and the DHPs were obtained selectively in 1,4-dioxane as a solvent. Various 2,6-unsubstituted DHPs were synthesized in one pot in satisfactory yields.

AB - The reaction of anilines, benzaldehydes, and ethyl 3,3-diethoxypropionate in the presence of Yb(OTf)3 proceeded under mild reaction conditions to give dihydropyridines (DHPs). We have found that the reaction depended on the solvent and the DHPs were obtained selectively in 1,4-dioxane as a solvent. Various 2,6-unsubstituted DHPs were synthesized in one pot in satisfactory yields.

KW - 2,6-Unsubstituted dihydropyridine

KW - DHP

KW - Multi-component coupling reaction

KW - Ytterbium catalyst

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DO - 10.1016/j.tetlet.2011.06.070

M3 - Article

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SN - 0040-4039

VL - 52

SP - 4473

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 34

ER -

Ytterbium-catalyzed synthesis of dihydropyridines

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